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MAMBA Research team

Modelling and Analysis for Medical and Biological Applications

Team presentation

Mamba is a team of researchers who come from applied mathematics, but also from computer science, statistical physics and medicine, and whose application domain is biology and medicine. The physiological or physical modelling of the complex and multiscale phenomena under study guide us to the mathematical analysis of partial differential equations, or to the use of simulation methods from statistical physics, and to the development of effective and reliable numerical methods.

Research themes

The MAMBA research team is a joint INRIA-Pierre-et-Marie-Curie University (UPMC) team that belongs to the INRIA theme "Health, Biology and Earth" (sub-theme "Modelling and Control for the Living"). Of particular interest for the MAMBA project-team are problems of mathematical biology related to cell movements and cell population growth, in particular for healthy or cancer cells, subject to intact or disrupted physiological control, and to the possible restoration of this normal control by drugs. Another important domain of application is the phenomena of growth-fragmentation of abnormal proteins (prions), which are a key mechanism to understand the development and propagation of amyloid diseases (Alzheimer's, Parkinson's, Creuzfelt-Jakob's, among others). Among other directions, and in collaboration with other research teams (see Collaborations), we are developing methods to optimise cancer pharmacotherapeutics from a molecular systems biology point of view, and simultaneously, to represent tissue growth in health or pathology, i.e., under normal or disrupted control, in a multiscale setting, in particular toward modelling for regenerative medicine. Close experimental collaborations, especially those which emerged through the former associate team QUANTISS (Dirk Drasdo), are key points in our project.

International and industrial relations

International collaborations: in addition to the close collaboration with the Quantiss associate team in Leipzig: * Marie Doumic within the ERC Starting Grant SKIPPER (principal investigator) * Dirk Drasdo within the EU Project NOTOX (coordinator: Elmar Heinzle, University of Saarbruecken) * Dirk Drasdo within the VIRTUAL LIVER NETWORK (German ministry of research, BMBF; program director: Adriano Henney) * Dirk Drasdo within the research network LUNGSYS/CANCERSYS (German ministry of research, BMBF, coordinator: Ursula Klingmueller, German Cancer Center, Heidelberg) * A long standing collaboration has been launched with Shanghai Jiaotong University after the postdoc of Min Tang at BANG. This has led to several research papers in common and support by a highly selective program by the Chinese Ministry of Education. MAMBA members have also developed numerous international collaborations, among which we can quote the long-term collaborations with Nikolaos Bournaveas (Univ.of Edinburgh, Scotland, UK), Jorge P. Zubelli (IMPA, Rio de Janeiro, Brazil), Patrizia Bagnerini (Univ. Genova), Antonio Jacinto (CEDOC, Lisbon), H.Thomas Banks’ team (NCSU, Raleigh, USA), etc.

Keywords: Structured populations; cancer modelling; protein aggregation; inverse problems; numerical analysis; computational biomechanics; individual-based models; liver regeneration; therapeutic optimization