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DRACULA Research team

Multi-scale modelling of cell dynamics : application to hematopoiesis

Team presentation

The Dracula team develops mathematical and computational tools, methods and approaches for multiscale modeling of biological processes. The aim is to describe processes involving interactions between molecular and cellular dynamics, with consequences on the fate of cell populations (e.g., death, proliferation, differentiation) and biological tissues, while accounting for the inherent stochasticity of most physiological processes. The main biological applications deal with the development of blood cells (white and red blood cells, platelets) and the treatment of leukemia, immune responses optimization and vaccine design, prion and Alzheimer's diseases, slowly proliferating cell renewal (e.g., cardiac cells, neurons). Dracula is a joint Inria-CNRS (ICJ UMR 5208 and LBMC UMR 5239) research team.

Research themes

Dracula team's main research themes are

  • The development of deterministic (ordinary, delay, and partial differential equations) and probabilistic multiscale models and their analysis
  • The development and study of statistical models (nonlinear mixed effects models)
  • The implementation of multiscale computational models (agent-based models, discrete-continuous hybrid models)
  • The development of efficient numerical methods

These works aims at answering biological questions dealing with genetic regulatory networks, extracellular dynamics, and cell population dynamics modeling, in the following research areas:

  • Blood cell production and leukemia treatment (in collaboration with the Hospices Civils de Lyon)
  • Immune responses to acute infections and vaccine design
  • Prions and Alzheimer's diseases
  • Slowly proliferating cell renewal (cardiac cells, neurons, etc.)
  • Differentiation in fastly renewing cell populations (blood cells)

International and industrial relations

Industrial Collaborations: AltraBio (SME, data analysis), Neolys Diagnostics (SME, individual-patient radiosensitivity), Sanofi Pasteur (vaccine design), The Cosmo Company (SME, complex systems modeling).

International Collaborations: McGill University (Montréal, Canada), Universitad de Valladolid (Valladolid, Spain), Karolinska University Hospital of Stockholm (Stockholm, Sweden), Cadi Ayyad Universty (Marrakech, Morocco), Polish Academy of Sciences (Warsaw, Poland), University of Maryland (Washington, USA), Abou Bekr Belkaid University of Tlemcen (Tlemcen, Algeria), Universidade Estadual Paulista (Botucatu, São Paulo, Brazil).

Keywords: Multiscale modeling Physiology Cell dynamics