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BIOCORE Research team

Biological control of artificial ecosystems

Team presentation

The BIOCORE project-team is the successor of the COMORE project-team.

BIOCORE is a joint INRIA (Research Unit in Sophia-Antipolis) , INRA (sites in Sophia Antipolis and LBE Narbonne) research-team, and UPMC/CNRS Oceanographic Laboratory of Villefranche-sur-mer (LOV).
The overall goal of BIOCORE is to contribute to environment preservation by developing new energy sources, avoiding water pollution and replacing the use of chemicals for crops. In this context, the objective is to design, model, analyze, control and optimize artificial ecosystems (designed by man, built by man, or profoundly modified by man).

Research themes

Mathematical and computational methods
Our tools are developed within the framework of the analysis of dynamic systems and control theory, which includes modeling, identification, validation based on experimental measurements, state estimation, control, optimization for dynamical systems.

A methodological approach to biology
Our methodology is based on a multi-model approach, considering simultaneously models which can concern the internal state of the individuals/cells (of genetic and/or metabolic type,...), models at the scale of the interaction between individuals, or models of the interacting populations at the scale of the ecosystems.


  • Bioenergy, in particular the production of lipids (which can be used as biofuel), methane and hydrogen by microorganisms (with LOV and LBE).
  • CO2 fixation, particularly by micro-algae, with the aim of capturing industrial CO2 fluxes (with LOV). This theme includes artificial ecosystems developed to improve the prediction of carbon fluxes between the ocean and atmosphere.
  • Design and optimization of ecologically friendly protection methods for plants and micro-plants artificial production systems (with URIH and LOV). This theme focuses in particular on biological control programs to prevent enemies invasions in greenhouse crops and bioreactors.
  • Biological waste treatment with microorganisms in bioreactors to reduce pollution emissions (in collaboration with LBE)

International and industrial relations

  • Collaboration with LOV CNRS/UPMC Villefranche, IFREMER (Nantes), INRA (MIA Montpellier, LBE Narbonne, GMPA Grignon, ISA Sophia-Antipolis), CIRAD Montpellier, Centre d'Océanologie de Marseille, LOCEAN (Paris), GIPSA Grenoble, IBIS, ANGE, DYLISS INRIA teams.
  • Université Catholique de Louvain (Belgium), University of Marrakech (Marocco), Faculté Polytechnique de Mons (Belgium), University of Stuttgart (Germany), Rutgers University (USA)
  • ANR project Facteur4.
  • ANR Project Funfit
  • ANR Project ICycle
  • ANR Bioinformatique RESET
  • ITE OPALE Project
  • ANR Project Phycover

Keywords: Biological models Control Bioreactor Bioenergy Biosystems Ecosystems