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Large-scale simulation can help in deciding on the right strategy for curbing animal epidemics. But that requires a lot of computing power. Hence the idea of using cloud computing. The problem? Existing applications have never been designed to take advantage of the high elasticity of such an architecture. Developed at the Inria Rennes – Bretagne Atlantique centre, DiFFuSE is a new framework enabling not only the design and management of simulations operating on the cloud, but also the conversion of old applications to enable them to exploit this distributed infrastructure. As part of a future consortium, DiFFuSE will be used to create new decision-making tools for the animal health sector.