SISYPHE Research team

SIgnals and SYstems in PHysiology & Engineering

Team presentation

SISYPHE is dealing with questions raised by some complex dynamical systems issued from Physiology and Engineering: modeling; identification and observation from signals; control. We consider multi-scale or networked dynamical systems involving exchanges of energy or control information among scales and sub-systems. Most studies are motivated by the cardiovascular and reproductive systems or by some energy conversion systems for low-emission vehicles. We consider systems and associated signals together, as coupling models and measured data is necessary for monitoring or real-time control. Some clinical or engineering applications are studied within academic or industrial collaborations.

Research themes

  • Reduced order modeling, observation and control of isolated cells or multi-cell systems (ovarian follicles, cardiac cells, fuel-cell stacks...). Cells are represented by differential models.
  • Analysis of some phenomena in networks of dynamical systems: excitability and travelling waves; scattering of waves & inverse scattering, synchronization of sub-systems.
  • Analysis of multiscale properties of signals and relations with the underlying dynamical systems.
  • Identification and control of quantum systems.
  • Model-based observation of the cardiovascular system and its short-term control & signal processing of the arterial pressure and ECG.
  • Multiscale modeling of the controlled follicles selection process (ovulation control).
  • Analysis of travelling pulses in networks (arterial tree or cabled electrical transmission networks) and application to diagnosis.

International and industrial relations

We have long-term collaborations with:
  • Biomedical - A. Béclère Hospital (Clamart), Kremlin-Bicêtre Hospital, Evry University (STAPS department & LEPHE) INRA (Tours), CardioSense3D (an Inria Large Initiative Action focusing on clinical applications of electro-mechanical models of the heart, and involving academic, clinical and industrial partners).
  • Engineering - CEA-LIST (Saclay), EDF, Renault, Fuel Cell Lab (Belfort), Supelec-LGEP (Gif-sur-Yvette).
European partnerships: European Control Training Site; HYCON network of excellence; INRIA-FAPESP Cooperation ParaSDP.

Academic collaborations: Paris 6 University, Paris 11-South University, UVSQ, Ecole des Mines de Paris (Systems and Control Centre), CNRS-LAAS (Toulouse), Caltech (MURI Center for Quantum Networks), Georgia Tech (Dynamics and control systems laboratory), Weierstrass Institute for Applied Analysis and Stochastics, University of Firenze, Unicamp (Campinas, Brazil), Tsinghua University (Beijing), Monastir University (Tunisia), Linkoping University (Sweden).

Keywords: Modeling Control Monitoring Complex dynamical systems Physiological systems Energy conversion

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